Current Therapeutic Approach
Alector's Therapeutic Approach
There is a gap in our understanding of the mechanism of neuro-degenerative disease. Historically, we believed that microglia, immune cells in the brain, were merely responding to disease. A few years ago, genome-wide association studies (GWAS) identified new gene variants that increase or decrease the chance of developing neuro-degenerative disease. Surprisingly, a large fraction of these are immune genes primarily expressed in the microglia, suggesting that these cells not only respond to disease, but can also actively drive neuronal degeneration. By targeting immune genes tied to these specific diseases, we can improve the function of the immune system and halt progression of the disease.