Here are some publications related to the work Alector is doing to advance the science on immuno-neurology for the treatment of neurodegenerative disorders.
Shifting paradigms: The central role of microglia in Alzheimer's disease
Neurobiology of Disease, 2019
Microglia in Neurodegeneration
Nature Neuroscience, 2018
Molecular Neurodegeneration, 2018
Journal of Neurochemistry, 2017
Journal of Neurochemistry, 2017
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
Journal of Cell Biology, 2015
Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis
Journal of Neurology, 2015
Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene
Molecular Neurodegeneration, 2014
Progranulin regulates neuronal outgrowth independent of Sortilin
Molecular Neurodegeneration, 2012
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice
The Journal of Experimental Medicine, 2010
The Journal of Experimental Medicine, 2020
TREM2 function impedes tau seeding in neuritic plaques
Nature Neuroscience, 2019
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
European Molecular Biology Organization, 2017
A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese
Neurobiology of Aging, 2016
TREM2 and neurodegenerative disease
New England Journal of Medicine, 2013
TREM2 variants in Alzheimer's disease
New England Journal of Medicine, 2013