Here are some publications related to the work Alector is doing to advance the science on immuno-neurology for the treatment of neurodegenerative disorders.
Shifting paradigms: The central role of microglia in Alzheimer's disease
Neurobiology of Disease, 2019
Microglia in Neurodegeneration
Nature Neuroscience, 2018
Phase 1 study of latozinemab in progranulin-associated frontotemporal dementia
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2024
Targeting Progranulin as an Immuno-Neurology Therapeutic Approach
International Journal of Molecular Sciences, 2023
Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia
Journal of Translational Medicine, 2023
Temporal order of clinical and biomarker changes in familial frontotemporal dementia
Nature Medicine, 2022
Progranulin as a therapeutic target in neurodegenerative diseases
Trends in Pharmacological Sciences, 2022
Reduced plasma progranulin levels are associated with the severity of Parkinson's disease
Neuroscience Letters, 2020
Molecular Neurodegeneration, 2018
Journal of Neurochemistry, 2017
Journal of Neurochemistry, 2017
Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling
Molecular Neurodegeneration, 2016
Association Between Progranulin and Gaucher Disease
EBioMedicine, 2016
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
Journal of Cell Biology, 2015
Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis
Journal of Neurology, 2015
Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene
Molecular Neurodegeneration, 2014
Progranulin regulates neuronal outgrowth independent of Sortilin
Molecular Neurodegeneration, 2012
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice
The Journal of Experimental Medicine, 2010
Science Translational Medicine, 2022
Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia
Journal of Experimental Medicine, 2022
Targeting TREM2 for Parkinson’s Disease: Where to Go?
Frontiers in Immunology, 2021
The Journal of Experimental Medicine, 2020
TREM2 function impedes tau seeding in neuritic plaques
Nature Neuroscience, 2019
Journal of Biological Chemistry, 2018
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
European Molecular Biology Organization, 2017
A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese
Neurobiology of Aging, 2016
TREM2 regulates microglial cell activation in response to demyelination in vivo
Acta Neuropathologica, 2015
The TREM2 variant p.R47H is a risk factor for sporadic amyotrophic lateral sclerosis
JAMA Neurology, 2014
TREM2 and neurodegenerative disease
New England Journal of Medicine, 2013
TREM2 variants in Alzheimer's disease
New England Journal of Medicine, 2013