Publications

Shifting paradigms: The central role of microglia in Alzheimer's disease

Neurobiology of Disease, 2019

Microglia in Neurodegeneration

Nature Neuroscience, 2018

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

Molecular Neurodegeneration, 2018

The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C

Journal of Neurochemistry, 2017

Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access

Journal of Neurochemistry, 2017

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Journal of Cell Biology, 2015

Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis

Journal of Neurology, 2015

Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene

Molecular Neurodegeneration, 2014

Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease

Gene, 2014

Progranulin regulates neuronal outgrowth independent of Sortilin

Molecular Neurodegeneration, 2012

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin

Neuron, 2010

Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy

PLoS ONE, 2010

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

The Journal of Experimental Medicine, 2010

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Nature, 2006

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Acta Neuropathologica, 2020

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

The Journal of Experimental Medicine, 2020

TREM2 function impedes tau seeding in neuritic plaques

Nature Neuroscience, 2019

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Cell., 2017

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Immunity, 2017

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

European Molecular Biology Organization, 2017

A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese

Neurobiology of Aging, 2016

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

Neuron, 2016

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

Cell., 2015

TREM2 and neurodegenerative disease

New England Journal of Medicine, 2013

TREM2 variants in Alzheimer's disease

New England Journal of Medicine, 2013